Contact Us
Contact Us
Blog Posts

Meet the Team – Our Engineer, Yuki Higa

For the next installation in the “Meet the Team” series, we hear from Yuki Higa, a Process Engineer at Antheia. Read on to learn about Yuki’s fast-paced work in a downstream processing group.

What is downstream processing?

The high-level goal of downstream processing, or DSP, is to purify the broth produced by our fermentation tanks to create a usable product. The fermentation team will deliver the broth produced to the DSP group to essentially clean it up. There are impurities in the fermentation broth when it is first produced and our job is to remove as many of those as possible to get a clean and usable product at the end. A lot of the techniques we use in the lab take advantage of how the main molecule we’re aiming to isolate reacts in various environments.

Essentially, we’re the last group to touch the product before we ship it to the customer. Because of this, DSP is key for commercialization as our team provides the technical details and support required to produce large amounts of product at a manufacturing plant. During the manufacturing phase, if the product quality is not as expected, the DSP group can help troubleshoot and propose solutions to fix and prevent future problems.

Tell us about your background.

I did my undergrad at UC Berkeley, studying chemistry. I’ve always been interested in science, and was drawn toward chemistry – I enjoyed that it was a more controllable discipline. After college, many of my peers at UC Berkeley decided to pursue PhD programs in chemistry, but I was eager to enter the job force, so I pursued a chemical engineering master’s program at UC Irvine as a launch pad for a career.

After graduation, I started my professional career at Amyris doing similar work to what I’m doing today – namely conducting bench experiments and achieving pilot and manufacturing scale. I gained such valuable hands-on experience learning how to design experiments and analyze data, which has translated seamlessly to my work at Antheia.

I also met Suzy, my current manager, while at Amyris – she was a big reason I chose to come work at Antheia. She has been a great mentor to me and has helped me – along with many others – in our work in and outside of the lab. When you’re in the trenches, it can be hard to see the bigger picture, but one of Suzy’s strengths is making sure the pieces fit together so our work is successful and impactful.

What is your typical day like?

I work in process engineering, which is essentially the bridge between research and manufacturing. My team makes it possible to scale our work by creating processes at the bench scale and then using those parameters to inform our work at the pilot and manufacturing scale. As I focus on downstream processing, I’m most concerned about purification – my team takes the product from the fermentation team and purifies it, so that it meets all the customer specifications.

Most days, I split my time between benchwork and deskwork. The benchwork generally involves running experiments and analyzing the resulting data. It’s nuanced work since we do have to often make small adjustments, then run the experiments again. When we’re not doing benchwork, the team is generally doing literature research on various purification processes that have been used in the past to inform our own approach and inform the direction we take for our own purification pathway.

Lately, I’ve been researching new equipment to bring into the lab, as Antheia is in the process of expanding its downstream processes. I’ve been working to understand exactly what we need to replicate our protocols at the pilot and manufacturing scale, which gives us valuable data for future experiments. There is a lot of nuanced industry knowledge involved in this process, so having the opportunity to dig deep into this research will ultimately increase Antheia’s success rate when delivering final products and widen our competitive advantage.

What’s your favorite part of your job, or the project you’re working on that you are most excited about?

I like to see my processes going to pilot or manufacturing. It’s validating to know that the data I’m gathering at the bench is strong enough to use at that scale, and it tells me that I’m designing experiments correctly and collecting usable data. Just this year, we went to a manufacturing facility to run a few experiments and they resembled what we saw at the pilot scale, which is always rewarding.

What’s the most unique part of your day-to-day?

The most unique part of being on the DSP team is the ability to see the full range of equipment and how your process translates across scales. We start off at a small scale in the lab, then see it translate to the pilot, and finally, at manufacturing scale. Many people, especially those that work at large companies, don’t get to see how their final product is made and aren’t familiar with the in-depth process and logistics behind it. Working at Antheia gives me the unique opportunity of being able to track a project along its lifespan.

What is your high-level impact at the company?

I see a direct connection between my work in the lab and the final product being delivered to our manufacturing partner. We went to pilot at the beginning of the year and created a proof of concept product that was shared with the customer and implemented into their process for evaluation. This is a clear demonstration of my team’s impact – helping a partner take an idea from conceptualization to commercialization.

What are you looking forward to most in Antheia’s future?

I’m most looking forward to going to manufacturing to see this process all the way through. I really believe in Antheia’s mission and our platform for transforming the supply chain for plant-based medicines – seeing how close we are to manufacturing scale is a significant milestone and I’m excited to reach it with this team.

Interested in learning more about our team? Read more about our Scientist (Ken) and RA (Cat).

*Photo credits: Daniel Yim

Richard Sherwin

Head of Commercialization

Richard is an industry veteran with more than 30 years of experience in the KSM, API, and intermediate markets. He is responsible for leading the commercialization and revenue generation for Antheia’s robust pipeline of products. Richard brings an exceptional track record of leading international sales teams, driving revenue growth, building strategic partnerships, and delivering innovative products to market, including ANDA and NDA developments. Richard led commercial efforts at some of the leading global pharmaceutical companies and most recently, built his own consultancy business advising a range of clients, including $1B divisions of major multinationals.

Appropriate regulatory submissions will be prepared and submitted to support Antheia’s customers who need to reference and access necessary process-related information.

Yihui Zhu, PhD

Head of Fermentation

Yihui leads the fermentation team at Antheia. With over 25 years of hands-on experience in the field, he brings in-depth knowledge and expertise in microbial metabolism and fermentation process development. He is also skilled in developing comprehensive fermentation data collection, analysis, and visualization systems. Prior to joining Antheia, he served as a fermentation lead at Intrexon and Codexis where he successfully built fermentation labs and teams and led multiple biofuel and biochemical projects to reach stretch milestones and tech transfer. Yihui is passionate about the potential of fermentation and is dedicated to advancing the field through innovative research and development.

Yen-Hsiang Wang, PhD

Head of Strategy, Partnerships, and Finance

Yen-Hsiang leads strategy, partnerships and finance at Antheia. He completed his M.S. and Ph.D. in Bioengineering at Stanford, with extensive research experience in synthetic biology, metabolic engineering and computational modeling. Before joining Antheia, he worked at McKinsey and Tencent with a strong focus in corporate strategy and big data/advanced analytics. At Tencent, he served as Director of Strategy and Business Development for the AI Lab, leading corporate initiatives in healthcare AI/ML applications and commercialization. He also served in AI4H (Artificial Intelligence for Health), a collaboration between WHO and ITU, to establish global standards for AI in healthcare.

Audrey Wang

Head of Financial Planning and Analysis

Audrey leads financial planning and analysis at Antheia. With an MBA from Washington University in St. Louis, Audrey is passionate about leveraging financial analysis, digital technology, and data analytics to guide companies in making optimal investments and strategic business decisions. Audrey has a decade of experience in helping companies solve unique problems and creating long-term impact with unconventional approaches. Before joining Antheia, she was at Vir Biotechnology and Merck where she led various FP&A workstreams, including investment valuation, asset prioritization, and manufacturing sites operation finance support. Audrey completed CFA Level II and passed the U.S. CPA exam in 2011.

Antonij Tjahjadi, CPA

Head of Accounting

Antonij Tjahjadi leads accounting at Antheia and holds active CPA license. He joined Antheia with more than 20 years of experience in corporate accounting, bringing deep expertise in ramping up accounting operations for start-up companies, SEC reporting/technical accounting, and SOX implementation efforts. Before joining Antheia, he held various leading roles in both public and private company settings, including directing accounting functions at Ambys Medicines, where he successfully implemented Netsuite with Point Purchasing integration and set up various accounting policies and processes, and played a key role in the initial public offering of Nutanix, Inc.

Ken Takeoka

Head of Biology

Ken leads the Biology team at Antheia, which incorporates both strain and protein engineering functions. He has more than 16 years of experience in the synthetic biology field, working with leading companies, including Amyris and Novartis. One of his passions is molecular biology tool development and he previously worked to build the foundation for the automated strain engineering pipeline at Amyris. At Novartis, he modernized the molecular biology techniques and established a platform to model mechanisms of antibiotic resistance in a range of organisms.

Suzanne Sato

Head of Downstream Processing

Suzy leads downstream chemistry processes at Antheia. She has 19 years of experience in process development, including route development through synthetic chemistry and scale-up of small molecule APIs for GPCR targets under cGMP for Phase I-III trials. Before joining Antheia, Suzy led a full DSP team at Amyris where she successfully pivoted developments from biofuels hydrocarbon products to pharmaceutical intermediate, flavor, fragrance and nutraceutical products. She led a team that scaled 11 products and took five products to commercial manufacturing.

Farrah Pulce, PMP

Head of Project Management

Farrah leads program and project management at Antheia. She has over 20 years of experience leading program and project management, operations, and engineering for companies across the CPG, aerospace, and automotive industries. Prior to joining Antheia, Farrah implemented and led the sustaining program management team at Impossible Foods. She also led product operations, project management, and cost optimization at Blue Bottle Coffee and Tyson Foods to develop and commercialize new products. As a certified project management professional (PMP), Farrah has a proven record of successful project delivery, improving project management practices, and building collaborative teams.

Jordyn Lee

Head of Communications

Jordyn leads communications and external affairs at Antheia. She brings a decade of multidisciplinary communications experience in helping companies make complex science and technology accessible to broad audiences, all while maintaining technical accuracy and integrity. She has a passion for visionary storytelling and translating impact across the entire communications ecosystem – her work has spanned from public relations to corporate communications to marketing. Jordyn has served as an advisor to a number of different life sciences companies and most recently led corporate communications at Amyris.

Ben Kotopka, PhD

Head of Data Science

As Head of Data Science at Antheia, Ben manages in-house software development and external partnerships for storing and interpreting research data, executing bioinformatics analyses, and streamlining business processes. Prior to Antheia, Ben worked as an academic researcher at the intersection of machine learning, bioinformatics, and synthetic biology. Following this, as an entrepreneur and consultant, he developed and deployed data science solutions for biotechnology applications ranging from metabolomics-driven compound discovery to MRI segmentation.

Guerin Kob

Head of Supply Chain

Guerin is responsible for leading the design, development, management and improvement of Antheia’s end-to-end global supply chain. He has over 15 years of experience leading high-performing supply chain and procurement teams at leading biotechnology and specialty chemical companies, with extensive experience in process development and end-to-end supply chain optimization. Prior to joining Antheia, Guerin served as Senior Director of Global Supply Chain for Sumitomo Chemical’s biotechnology division with Valent Biosciences, where he led the end-to end supply chain including procurement, logistics and distribution, integrated business planning, materials management, customer service, and supply planning functions globally.

Pavel Aronov, PhD

Head of Bioanalytics

Pavel leads the Bioanalytics team at Antheia. He has 20 years of experience in analytical and clinical chemistry, mass spectrometry, chromatography, and metabolomics. Pavel built and led the original Chemistry and Analytics team at Impossible Foods enabling strain development, fermentation, DSP, regulatory, QC, and scale-up of leghemoglobin biomanufacturing. During his academic career at UC Davis and Stanford University Pavel developed a vitamin D assay used by all major clinical diagnostics laboratories and pioneered metabolomics studies to investigate kidney disease and microbiome.

Jesse Ahrendt

Head of Quality Assurance and Regulatory Affairs

Jesse has more than 25 years of experience in regulatory affairs, quality systems, manufacturing quality, and regulated industries, ranging from early- to late-stage pharmaceuticals, biomanufacturing, consumer care, and medical devices. He has supported global product launches and the underlying quality supply chain components in industries that require strict adherence to internationally accepted quality standards. Before Antheia, he led quality efforts at Zymergen and Sandoz, and supported many global pharmaceutical companies during his time in Biotech Consulting at NSF International, all to bring quality to the forefront in manufacturing, standardize global processes, and support customer regulatory requirements.

Heidi Pucel

Chief People Officer

Heidi is a results-driven human resources executive and HR business partner who leverages decades of experience in empowering, motivating, and inspiring to drive transformation within high-performing and rapidly-growing workforces. A certified executive coach and passionate advocate for people-oriented solutions, Pucel serves as a partner to executive teams to design programs that support employee development, engagement, and recruitment and retention. Pucel most recently served as Chief People Officer for Countsy, where she worked as an interim HR executive for clients in the biotechnology and software industries, such as Ceribell and Tune Therapeutics.

Zack McGahey

Chief Operating Officer

Zack is a leading executive in operations management, specializing in bioprocess engineering and manufacturing management. He has over 20 years of experience leading manufacturing functions for companies across the pharmaceutical, synthetic biology, diagnostics, and automotive industries. Before joining Antheia, Zack was VP of manufacturing and capex project management at Zymergen. He also gained experience managing commercial scale facilities operations for Tesla, where he was responsible for managing 10 million square feet of factory, lab and warehouse space during the Model 3 ramp.

Kristy Hawkins, PhD

Co-Founder & CSO

Kristy has over 20 years of experience in the field of synthetic biology, focusing on yeast metabolic engineering for the production of small molecules. She did the founding work on the benzylisoquinoline alkaloid pathway during her graduate studies and gained valuable industry experience at Amyris and Lygos. Kristy is an expert in tool development, high-throughput screening, and host strain and heterologous pathway engineering.

Christina Smolke, PhD

Co-Founder & CEO

Christina is a pioneer in synthetic biology and metabolic engineering, where she has over 20 years of experience. As Professor of Bioengineering and Chemical Engineering at Stanford University, her laboratory led the breakthrough research to engineer baker’s yeast to produce some of the most complex and valuable medicines known. Under her leadership, Antheia’s synthetic biology platform enables new possibilities for drug discovery and efficient, sustainable, transparent, and on-demand drug manufacturing at scale. Her vision and accomplishments have garnered numerous awards, including the Chan-Zuckerberg Biohub Investigator, NIH Director’s Pioneer Award, Nature’s 10, Novozymes Award for Excellence in Biochemical Engineering, and TR35 Award.

Antheia Announces Continued Partnership with Olon

Appropriate regulatory submissions will be prepared and submitted to support Antheia’s customers who need to reference and access necessary process-related information.